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Preferentially expressed antigen
in melanoma (PRAME) is a tumour-
associated antigen that is
preferentially expressed in human
melanomas recognised by
Cytolytic T Lymphocytes. Normal
tissues show low or no expression (except testis, ovary, placenta, adrenals and endometrium), therefore it is called a member of the family of cancer testis antigens.
PRAME is also expressed in malignant cells, including leukaemias, Hodgkin's lymphoma and breast cancer.
This antibody can be used as a melanoma marker to differentiate between benign and malignant tumours.