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PRAME

Preferentially expressed antigen

in melanoma (PRAME) is a tumour-

associated antigen that is

preferentially expressed in human

melanomas recognised by

Cytolytic T Lymphocytes. Normal

tissues show low or no expression (except testis, ovary, placenta, adrenals and endometrium), therefore it is called a member of the family of cancer testis antigens. 

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PRAME is also expressed in malignant cells, including leukaemias, Hodgkin's lymphoma and breast cancer.

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This antibody can be used as a melanoma marker to differentiate between benign and malignant tumours.