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PRAME (preferentially expressed antigen in melanoma) is a tumour-associated antigen that is preferentially expressed in human melanomas, recognised by Cytolytic T Lymphocytes. Normal tissues show low or no expression (except testis, ovary, placenta, adrenals and endometrium,

therefore it is called a member of the family testis antigens. 


PRAME is also expressed in malignant cells, including leukaemias, Hodgkin'slymphoma and breast cancer. This antibody can be used as a melanoma marker to differenciate benign from mailign tumours.